Hemoglobin M equon beta 41 (C7) phenylalanine leads to tyrosine

Hemoglobin Philly ( p 35 Tyrosine Phenylalanine ) : Studies in

Received for publication 24 January 1969. INTRODUCTION The severity of the clinical manifestations of the different abnormal hemoglobins is varied. Many of these mutant proteins produce no discernible effect on the patient, while some cause a mild compensated hemolysis, and others are associated with severe hemolytic disease (1). The detection of an abnormal hemoglobin in many patients presenti...

The enzymatic conversion of phenylalanine to tyrosine.

The enzymatic oxidation of phenylalanine to tyrosine has been studied as part of an investigation of the intermediates and enzyme systems involved in the biosynthesis of epinephrine. Womack and Rose (1) indicated that phenylalanine was converted to tyrosine in viva by showing that tyrosine is not essential when sufficient phenylalanine is available. Definite proof was provided by Moss and Schoe...

Liver phenylalanine hydroxylase activity in relation to blood concentrations of tyrosine and phenylalanine in the rat.

The plasma concentration of phenylalanine and tyrosine decreases in normal rats during the first few postnatal days; subsequently, the concentration of phenylalanine remains more or less constant, whereas that of tyrosine exhibits a high peak on day 13. The basal concentrations of the two amino acids were not altered by injections of thyroxine or cortisol, except in 13-day-old rats, when an inj...

Phenylalanine Hydroxylase, Tyrosine Hydroxylase, and Tryptophan Hydroxylase

Phenylalanine-Tyrosine Biosynthesis in NEUROSPORA CRASSA.

IOCHEMICAL investigations of the phenylalanine-tyrosine specific portion of the aromatic pathmway reveal a reaction sequence depicted in Figure 1. Although the organisms studied use similar intermediates to accomplish phenylalanine and tyrosine synthesis, some important functional differences exist. Aerobacter aerogenes and Escherichia coli W possess two molecular forms of chorismate mutase sep...